Abstract
Compounds containing the 8-hydroxyquinoline (8-HQ) 1 nucleus exhibit a wide range of biological activities, including antimicrobial, anticancer, and antifungal effects. The chemistry and biology of this group have attracted the attention of chemists, medicinal chemists, and professionals in health sciences. A number of prescribed drugs incorporate this group, and numerous 8-HQ- based molecules can be used to develop potent lead compounds with good efficacy and low toxicity. This review focusses on the recent advances in the synthesis of 8-HQ derivatives with different pharmacological properties, including anticancer, antiviral, and antibacterial activities. For this purpose, recent relevant references were searched in different known databases and search engines, such as MEDLINE (PubMed), Google Scholar, Science Direct, Scopus, Cochrane, Scientific Information Database (SID), SciFinder, and Institute for Scientific Information (ISI) Web of Knowledge. This review article provides a literature overview of the various synthetic strategies and biological activities of 8-HQ derivatives and covers the recent related literature. Taken together, compounds containing the 8-HQ moiety have huge therapeutic value and can act as potential building blocks for various pharmacologically active scaffolds. In addition, several described compounds in this review could act leads for the development of drugs against numerous diseases including cancer.
Highlights
The mechanism of action was investigated and the results showed that these two derivatives are not virucidal, but appear to act at an early stage of the virus lifecycle, reducing the intracellular production ofScheme the envelope glycoprotein and2-isobutyl-5,7-dichloro-8-hydroxyquinoline the yield of infectious virions in treated
The results indicated that concentrations (MICs) promise were determined via Gram-positive the agar dilution method
The 8-hydroxyquinoline moiety can act as a building block for various pharmacologically active scaffolds
Summary
8-Hydroxyquinoline derivatives are an important group of compounds with rich and diverse biological activities. These compounds incorporate the 8-hydroxyquinoline (8-HQ) moiety, which is a bicyclic compound that consists of a pyridine ring fused to phenol, in which the hydroxyl group is attached to position 8 [1]. In this respect, the pyridine ring maintains its properties as an electron-deficient entity with a basic nitrogen. Focuses on currentofknowledge the synthetic of along novel with derivatives, along biological with the activities and medicinal applications. For thisreferences purpose, have recentbeen relevant references have been obtainedsuch from
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