Abstract
Postoperative adhesions are one of the clinically significant complications of almost all surgeries, leading to lifelong problems. To date, three strategies have been introduced to prevent or reduce the formation of these fibrous bands, including implementation of physical barriers, local or systemic administration of pharmacological agents, or a combination of both at the site of postsurgical traumatized tissue. This so far unsolved challenge has prompted scientists to focus on developing more effective preventative therapies. In this review, we aimed to provide a detailed overview of drug-free and drug-incorporated anti-adhesion barrier membranes and micro/nano-drug delivery systems implemented for postoperative adhesion prevention. The formulation components, the mean particle sizes of the particulate-based systems, release behavior of pharmacologic agents, and various evaluation methods determining the in vivo efficacy of the prepared systems in animal models including scoring, gross evaluation, Western blot, polymerase chain reaction (PCR), tissue scanning electron microscopy (SEM), enzyme-linked immunosorbent assay (ELISA), histological and immunohistochemical analyses were identified and discussed. Although a great number of studies have focused on the preparation and evaluation of the anti-adhesion efficacy of drug-free or drug-loaded anti-adhesion systems, further sophisticated research is required to develop effective and safe anti-adhesion products for clinical application.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.