Abstract
Friedreich’s ataxia (FRDA) is the most prevalent autosomic recessive ataxia and is associated with a severe cardiac hypertrophy and less frequently diabetes. It is caused by mutations in the gene encoding frataxin (FXN), a small mitochondrial protein. The primary consequence is a defective expression of FXN, with basal protein levels decreased by 70–98%, which foremost affects the cerebellum, dorsal root ganglia, heart and liver. FXN is a mitochondrial protein involved in iron metabolism but its exact function has remained elusive and highly debated since its discovery. At the cellular level, FRDA is characterized by a general deficit in the biosynthesis of iron-sulfur (Fe-S) clusters and heme, iron accumulation and deposition in mitochondria, and sensitivity to oxidative stress. Based on these phenotypes and the proposed ability of FXN to bind iron, a role as an iron storage protein providing iron for Fe-S cluster and heme biosynthesis was initially proposed. However, this model was challenged by several other studies and it is now widely accepted that FXN functions primarily in Fe-S cluster biosynthesis, with iron accumulation, heme deficiency and oxidative stress sensitivity appearing later on as secondary defects. Nonetheless, the biochemical function of FXN in Fe-S cluster biosynthesis is still debated. Several roles have been proposed for FXN: iron chaperone, gate-keeper of detrimental Fe-S cluster biosynthesis, sulfide production stimulator and sulfur transfer accelerator. A picture is now emerging which points toward a unique function of FXN as an accelerator of a key step of sulfur transfer between two components of the Fe-S cluster biosynthetic complex. These findings should foster the development of new strategies for the treatment of FRDA. We will review here the latest discoveries on the biochemical function of frataxin and the implication for a potential therapeutic treatment of FRDA.
Highlights
The severe neurological disease Friedreich’s Ataxia (FRDA) is the most frequent hereditary autosomal recessive ataxia with an incidence of about 30,000 in the Caucasian population and a carrier rate near 1:100 (Delatycki et al, 2000; Synofzik and Németh, 2018)
The disease was first described by Dr Nikolaus Friedreich in the mid-19th century, Biochemical Function of Frataxin who documented the pathology of several patients suffering from “degenerative atrophy of spinal posterior column” and heart problems related to hypertrophic cardiomyopathy, which was confirmed by later studies to be the dominant cause of death characterized by left ventricular hypertrophy, smaller left ventricular diastolic diameters and volumes, increased wall thicknesses and arrhythmia (Friedreich, 1863; Tsou et al, 2011)
Friedreich’s ataxia is caused by mutations on chromosome 9, in the gene coding for the frataxin protein (FXN) (Chamberlain et al, 1988; Campuzano et al, 1996)
Summary
The severe neurological disease Friedreich’s Ataxia (FRDA) is the most frequent hereditary autosomal recessive ataxia with an incidence of about 30,000 in the Caucasian population (people with European ancestry) and a carrier rate near 1:100 (Delatycki et al, 2000; Synofzik and Németh, 2018).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
