Abstract
AbstractCoumarin is a highly proficient scaffold with great effectiveness which uplifts emerging chemists to create coumarin derivatives using cutting‐edge synthetic techniques. However, severe reaction conditions are required to develop substituted coumarin analogous. Notably, the carboxylic acid group in coumarin has emerged as a flexible functionality facilitating the construction of coumarin‐containing building blocks, emphasizing the decarboxylative strategy. Use of the decarboxylative technique has tremendously increased, due to its ability to increase the reactivity of the substrate. Moreover, it is the most extensively investigated synthetic strategy incorporating various functionalities in coumarin nuclei. This review discusses the decarboxylative strategies for creating C‐3 and C‐4 substituted coumarin derivatives. It emphasizes various interactions, including catalyst‐based, catalyst‐free, Michael addition, cyclo addition, three components, oxidative, and photocatalytic system involving the decarboxylation process.
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