Abstract
Asymmetric synthesis is pivotal in modern-day organic synthesis in which metal-catalyzed protocols with compatible ligands play a key role. Many metal-chiral ligand combinations have been extensively reported in which “pybox” as the chiral ligand has occupied an indisputable place owing to its widespread use. This review focuses on the reactions of various metal-pybox combinations for the creation of asymmetric carbon centres by carbon-heteroatom bond manipulations. For brevity and simplicity, these reactions are classified based on the metal used and the literature from 2006–2018 is covered.
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