Recent Advances in Synthesis of Pyrazole Derivatives using Functionalized Catalysts Immobilized on Silica

Abstract

AbstractThe pyrazole moiety is found as an integral structural unit in a variety of pharmacologically and agrochemically significant chemicals. The anti‐inflammatory (celecoxib), anti‐obesity (rimonabant), analgesic (difenamizole), antipsychotic (CDPPB), H2‐receptor agonist (betazole), and antidepressant (fezolamide) activities of pyrazole‐based drugs have demonstrated their pharmacological importance. Various synthetic methodologies have been devised as a result of the above‐mentioned advantages of pyrazole‐based compounds, including solvent‐free approach, catalyst‐free method, homogeneous catalysis, heterogeneous catalysis, microwave irradiation technique, ultrasonication, etc. In the area of heterogeneous catalysis, silica functionalized catalysts have garnered a lot of interest among diverse heterogeneous catalysts. The significant advancements in silica functionalized heterogeneous catalysts for the production of pyrazole‐based compounds are highlighted in this review.