Recent Advances in Synthesis, Medical Applications and Challenges for Gold-Coated Iron Oxide: Comprehensive Study.

Mohammed Ali Dheyab,Mahmood S Jameel,Azlan Abdul Aziz,Pegah Moradi Khaniabadi

doi:10.3390/nano11082147

Mohammed Ali Dheyab, Mahmood S Jameel + Show 2 more

Open Access

https://doi.org/10.3390/nano11082147

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Journal: Nanomaterials	Publication Date: Aug 23, 2021
Citations: 15	License type: CC BY 4.0

Affiliation: Universiti Sains Malaysia, Sultan Qaboos University

Abstract

Combining iron oxide nanoparticles (Fe3O4 NPs) and gold nanoparticles (Au NPs) in one nanostructure is a promising technique for various applications. Fe3O4 NPs have special supermagnetic attributes that allow them to be applied in different areas, and Au NPs stand out in biomaterials due to their oxidation resistance, chemical stability, and unique optical properties. Recent studies have generally defined the physicochemical properties of nanostructures without concentrating on a particular formation strategy. This detailed review provides a summary of the latest research on the formation strategy and applications of Fe3O4@Au. The diverse methods of synthesis of Fe3O4@Au NPs with different basic organic and inorganic improvements are introduced. The role and applicability of Au coating on the surface of Fe3O4 NPs schemes were explored. The 40 most relevant publications were identified and reviewed. The versatility of combining Fe3O4@Au NPs as an option for medical application is proven in catalysis, hyperthermia, biomedical imaging, drug delivery and protein separation.

Highlights

Core@shell nanoparticles, consist of two or more nanoparticles that contain a wide variety of organic as well as inorganic nanoparticles, where one serves as a core while the other is centered on the core and named the shell [1]
Various kinds of functional materials, including silica, polymers and Au have been formed on the Fe3O4 NPs surface to improve biocompatibility, chemical stability as well formed on the Fe3 O4 NPs surface to improve biocompatibility, chemical stability as well as as processability for broader applications [10,11]
The findings demonstrated that Fe3 O4 @Au NPs have the ability to be used as a phototherapeutic agent to enhance the eradication of breast cancer cells

Summary

Introduction

Core@shell nanoparticles, consist of two or more nanoparticles that contain a wide variety of organic as well as inorganic nanoparticles, where one serves as a core while the other is centered on the core and named the shell [1]. NPs, with the potential to be used as core or shell in a wide variety of materials, will reflect their satisfying distinctive properties and custom functions. Nanomaterials 2021, 11, 2147 size control, preventing aggregation via coating, precise dispersion and interaction, as well as the penetration of tissue and cell barriers all give Fe3O4 NPs an advantage over cell barriers all give Fe3 O4 NPs an advantage over other metal nanoparticles. Various kinds of functional materials, including silica, polymers and Au have been formed on the Fe3O4 NPs surface to improve biocompatibility, chemical stability as well formed on the Fe3 O4 NPs surface to improve biocompatibility, chemical stability as well as as processability for broader applications [10,11].

Synthesis

Synthesis Method

Schematic

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Conclusions and Challenges