Recent advances in radical-mediated transformations of 1,3-dienes

Abstract

1,3-Dienes are a class of easily accessible and versatile feedstock chemicals that can participate in a wide range of reactions to facilitate the synthesis of various valuable allylic compounds. In the past decades, radical methodology has emerged as a powerful tool for organic synthesis by virtue of the fact that diverse highly reactive radical species can usually be generated under mild, neutral and controlled conditions, and allow for rapid generation of molecular complexity. In this review, we critically illustrate the recent advances in the field of radical-mediated transformations of 1,3-dienes based on the different radical precursors and working modes. Wherever possible, particular emphasis is also put on the related mechanistic studies and synthetic applications.