Abstract
It is known that 2-quinolones are broadly applicable chemical structures in medicinal and agrochemical research as well as various functional materials. A number of current publications about their synthesis and their applications emphasize the importance of these small molecules. The early synthetic chemistry originated from the same principle of the classical Friedländer and Knorr procedures for the preparation of quinolines. The analogous processes were developed by applying new synthetic tools such as novel catalysts, the microwave irradiation method, etc., whereas recent innovations in new bond forming reactions have allowed for novel strategies to construct the core structures of 2-quinolones beyond the bond disconnections based on two classical reactions. Over the last few decades, some reviews on structure-based, catalyst-based, and bioactivity-based studies have been released. In this focused review, we extensively surveyed recent examples of one-pot reactions, particularly in view of modular approaches. Thus, the contents are categorized as three major sections (two-, three-, and four-component reactions) according to the number of reagents that ultimately compose atoms of the core structures of 2-quinolones. The collected synthetic methods are discussed from the perspectives of strategy, efficiency, selectivity, and reaction mechanism.
Highlights
Quinolone and its structural congeners are versatile chemical entities that are ubiquitously present as core structures of pharmaceuticals, agrochemicals, and functional organic materials
A comprehensive review by Silva covered palladium-catalyzed reactions for 2- and 4-quinolone synthesis, some of which are one-pot methods for the preparation of 2-quinolones [83]. This focused review aims to provide an extensive survey of recently developed one-pot intermolecular reactions to prepare functionalized 2-quinolone derivatives; it limits the scope to examples involving the construction of the core structures but not including mere functionalization of 2-quinolones
We give an overview of recent synthetic efforts for the construction of 2-quinolone scaffolds
Summary
Quinolone and its structural congeners are versatile chemical entities that are ubiquitously present as core structures of pharmaceuticals, agrochemicals, and functional organic materials. Holding high approaches two types of reaction: Knorr-type reaction practicality and scalability for setting a good platform for further functionalization, the two methods (Figure 3A). From remarkable advances that in the synthesis of this molecule varying strategies that originate reviews on the synthetic routes to 2-quinolones have been published; an overview of new Several standpoints of bond disconnections. A comprehensive review by Silva covered palladium-catalyzed reactions for 2- and 4-quinolone synthesis, some of which are one-pot methods for the preparation of 2-quinolones [83] This focused review aims to provide an extensive survey of recently developed one-pot intermolecular reactions to prepare functionalized 2-quinolone derivatives; it limits the scope to examples involving the construction of the core structures but not including mere functionalization of 2-quinolones.
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