Recent Advances in Omeprazole Drug Delivery Systems and Advantages of Magnetic Formulation - A Review

Abstract

This review presents about the new diverse drug delivery technologies of omeprazole and also to explore it advantages by formulating omeprazole into magnetic tablets. The first marketed proton pump inhibitor was the omeprazole which irreversibly alter the H+/K+ ATPase activity therefore inhibiting the secretion of gastric acid. The gastric parietal cells are responsible for the gastric acid secretion. It is an agent used to prevent infections like stomach ulcers caused by Helicobacter pylori and also diseases such as Zollinger-Ellison syndrome, Acid Related Dyspepsia. Nowadays, there are many researchers who have been working to enhance the dissolution, bioavailability of drug, therapeutic efficacy and patient compliance of the various formulations of the proton pump inhibitors. The development of various formulations up to date can be favourable for the drugs to reach their target site and results in effective drug action on its receptor. Even though reaching their target site, it couldn’t differentiate the normal cells and infected cells on the target site. Hence if we give it as a magnetic formulation, it can be controlled by external magnetic field to reach their target site without being acted upon the other sites. Keywords: Omeprazole; Chemistry; Nanoparticle; Microparticle; In situ gel; Capsule device; Targeted delivery; Magnetic system Running title: Recent advances in omeprazole drug delivery systems.