Abstract

Nontuberculous mycobacteria (NTM) are members of the Mycobacterium genus other than Mycobacterium tuberculosis complex and Mycobacterium leprae. NTM are widely distributed in the environment and are increasingly recognized as causes of chronic lung disease that can be challenging to treat. In this brief review, we consider recent developments in the ecology, epidemiology, natural history, and treatment of NTM lung disease with a focus on Mycobacterium avium complex (MAC) and Mycobacterium abscessus complex .

Highlights

  • Nontuberculous mycobacteria (NTM) are members of the Mycobacterium genus other than Mycobacterium tuberculosis complex and Mycobacterium leprae

  • We focus our discussion on Mycobacterium avium complex (MAC) and Mycobacterium abscessus complex

  • Data from the Cystic Fibrosis Foundation Patient Registry revealed that the annual prevalence of positive sputum cultures for NTM increased from 11% in 2010 to 13.4% in 201411

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Summary

Invited Reviewers

F1000 Faculty Reviews are written by members of the prestigious F1000 Faculty. They are commissioned and are peer reviewed before publication to ensure that the final, published version is comprehensive and accessible. The reviewers who approved the final version are listed with their names and affiliations. Any comments on the article can be found at the end of the article

Introduction
Nontuberculous Mycobacterial Sputum Positivity in Patients with Cystic
Reference Source
Variants during Bedaquiline Treatment of Mycobacterium intracellulare Lung
Findings
Open Peer Review
Full Text
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