Abstract
The advent and popularity of minimal access surgeries and micro-medicine techniques incur the current surge in the utilization of nanotechnology and nanodevices in medical fields. It is obvious that the observed marked increase in nanotechnology research and developments provides a future avenue that portrayed the destiny of neuromedicine and neurosurgery. In fact, it has been the cause for the realization of several potential benefits such as new procedures and therapeutic options for nervous system neoplasia, brain implantation, neuroprotection, nerve nanorepair, efficient drug delivery, nano diagnostic of neurological disease and disorders, nanoimaging, neurological manipulation using nanorobots and nanowires, real- time recording using nanowires arrays and nanocircuits etc. Certainly, nanotechnology is providing a future platform for further research and development in neuroscience and neurosurgery. However, despite the significant advances provided by nanotechnology in terms of neurosurgical procedures, modern neuroimaging and contrast media; still some significant limitations exist. Thus, the applications of nanotechnology in the field of neurosurgery and neuroscience need to be precisely understandable for more transparent and honest solutions to foster their medical potentials. This review examines the recent developments and potentials of the utilization of nanotechnology in Neuromedicine and Neurosurgery.
Highlights
The pathological correlation of brain lesions that led to the diagnosis of central nervous system (CNS) neoplasia, vascular lesions, and spinal disorders were documented to be due to the progressive affirmation of Neuroscience and Neurosurgery
Recent advances in nanotechnology: Potential prospects in Neuromedicine and Neurosurgery and organs in applications such as medical imaging,[12] nerve regeneration,[13] CNS neoplasia targeting etc. [14,15] Nowadays, with the aid of nanodevices that serves as contrasting agents, maximal safe resection of the brain tumours such as gliomas and pituitary adenomas are achieved via rendering using intraoperative magnetic resonance imaging (MRI) imaging technolog.[1]These kinds of nanoparticles can be effectively transported across blood brain barrier (BBB)
Avenue that portrayed the destiny of neuromedicine and neurosurgery, which will be anticipated to lead to the realization of potential benefits in addressing various difficult conditions of the nervous system encompassing gliomas and other malignant tumors, brain implantation, nerve injuries, efficient drug delivery, novel diagnostic imaging, real-time recording etc
Summary
The pathological correlation of brain lesions that led to the diagnosis of central nervous system (CNS) neoplasia, vascular lesions, and spinal disorders were documented to be due to the progressive affirmation of Neuroscience and Neurosurgery. The increasing need of specialized and intense neurosurgical operative procedures of higher sophistication, lack of skilled neuro-anaesthesia, difficulty in drug delivery across blood brain barrier (BBB), and lack of microsurgical instruments among other things were considered to be among the reasons of the associated mortality and morbidity This led to the urgent need for alternative therapeutic options in neuromedicine and neurosurgery. [14,15] Nowadays, with the aid of nanodevices that serves as contrasting agents, maximal safe resection of the brain tumours such as gliomas and pituitary adenomas are achieved via rendering using intraoperative MRI imaging technolog.[1]These kinds of nanoparticles can be effectively transported across BBB They were reported to demonstrat early preclinical success in management of CNS neoplasia, acute ischemic stroke, Alzheimer’s disease, and HIV encephalopathy.[16]. Adopted from[34] and[35] , with permission from Elsevier
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