Abstract
Conventional chemotherapy for cancer treatment is usually compromised by shortcomings such as insufficient therapeutic outcome and undesired side effects. The past decade has witnessed the rapid development of combination therapy by integrating chemotherapy with hyperthermia for enhanced therapeutic efficacy. Near-infrared (NIR) light-mediated photothermal therapy, which has advantages such as great capacity of heat ablation and minimally invasive manner, has emerged as a powerful approach for cancer treatment. A variety of nanomaterials absorbing NIR light to generate heat have been developed to simultaneously act as carriers for chemotherapeutic drugs, contributing as heat trigger for drug release and/or inducing hyperthermia for synergistic effects. This review aims to summarize the recent development of advanced nanomaterials in chemo-photothermal combination therapy, including metal-, carbon-based nanomaterials and particularly organic nanomaterials. The potential challenges and perspectives for the future development of nanomaterials-based chemo-photothermal therapy were also discussed.
Highlights
Traditional chemotherapy, typically the main treatment for late stage cancer or adjunct method for surgery in early stage cancer, usually suffers severe systemic toxicity due to the unspecific cytotoxicity of chemotherapeutic drugs for both cancerous and normal cells (Cobley et al, 2010; Mahmoudi et al, 2011; DeSantis et al, 2014)
Nanomaterials-Based Chemo-Photothermal Therapy for Cancer Treatment century (Mallory et al, 2016). It can be used alone, hyperthermia is most often used in combination with other therapeutic modalities including chemotherapy and radiation therapy
Hyperthermia typically falls under three categories: local hyperthermia, regional hyperthermia, and whole-body hyperthermia
Summary
Traditional chemotherapy, typically the main treatment for late stage cancer or adjunct method for surgery in early stage cancer, usually suffers severe systemic toxicity due to the unspecific cytotoxicity of chemotherapeutic drugs for both cancerous and normal cells (Cobley et al, 2010; Mahmoudi et al, 2011; DeSantis et al, 2014). Nanomaterials-Based Chemo-Photothermal Therapy for Cancer Treatment century (Mallory et al, 2016). It can be used alone, hyperthermia is most often used in combination with other therapeutic modalities including chemotherapy and radiation therapy. Clinical application of heat can be induced by radiofrequency, microwave, ultrasound, or perfusion methods (Falk and Issels, 2001). While these methods heat tissues efficiently, they cause either a risk of systemic toxicity from whole-body hyperthermia exposure, require invasive surgery or probe, or may damage normal tissues due to non-targeted heating in local region (Wust et al, 2002). The ease of control and focus enables better targeted treatments and leads to less damage in healthy tissues
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
