Recent Advances in MXene Nanocomposite-Based Biosensors.

Jinho Yoon,Minkyu Shin,Jeong-Woo Choi,Ji-Young Lee,Joungpyo Lim

doi:10.3390/bios10110185

Jinho Yoon, Minkyu Shin + Show 3 more

Open Access

https://doi.org/10.3390/bios10110185

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Abstract

The development of advanced biosensors with high sensitivity and selectivity is one of the most demanded concerns in the field of biosensors. To meet this requirement, up until now, numerous nanomaterials have been introduced to develop biosensors for achieving high sensitivity and selectivity. Among the latest nanomaterials attracting attention, MXene is one of the best materials for the development of biosensors because of its various superior properties. MXenes are two-dimensional inorganic compounds with few atomic layers that possess excellent characteristics including high conductivity and superior fluorescent, optical, and plasmonic properties. In this review, advanced biosensors developed on the basis of the MXene nanocomposite are discussed with the selective overview of recently reported studies. For this, introduction of the MXene including the definition, synthesis methods, and its properties are discussed. Next, MXene-based electrochemical biosensors and MXene-based fluorescent/optical biosensors are provided, which are developed on the basis of the exceptional properties of the MXene nanocomposite. This review will suggest the direction for use of the Mxene nanocomposite to develop advanced biosensors with high sensitivity and selectivity.

Highlights

The development of biosensors to detect biological and chemical molecules that affect disease or have harmful effects is a major field of study [1,2]
Among various recently reported nanomaterials, MXenes have attracted much attention because their exceptional properties make them suitable for the development of advanced biosensors. Since they were first reported, MXenes have been extensively studied for their potential for biosensor development
Recent studies on the development of biosensors based on the MXene nanocomposite have verified that MXenes are the best candidate among various nanomaterials for the development of various types of biosensors, including electrochemical, fluorescent, and optical biosensors, and still have huge potential for the development of next-generation biosensors such as wearable biosensing systems

Summary

Introduction

The development of biosensors to detect biological and chemical molecules that affect disease or have harmful effects is a major field of study [1,2]. The most important consideration in biosensor development is the accurate and rapid detection of target molecules to prevent the occurrence of diseases and to facilitate early medical treatment and thereby enhance the curative efficiency [3] For this purpose, high sensitivity and selectivity are the most important characteristics to be considered in the development of biosensors. The biocompatible property of MXenes enables their biomedical application [25,26,27] Since they were first reported in 2011, MXenes have been used to develop various types of advanced biosensors, including electrochemical, fluorescent/optical, and surface-enhanced Raman spectroscopy (SERS) biosensors, by augmenting. We strongly believe that this review can clarify the current research direction and methods for utilization of MXene nanocomposites to efficiently develop efficient biosensors with high sensitivity and selectivity

Definition of MXenes

HF Etching Method-Based MXenes and Characteristics

In Situ HF Etching Method-Based MXenes and Characteristics

Synthesis of MQDs and Characteristics

MXene-Based Electrochemical Biosensors

Conclusions and Future Perspectives