Abstract

This review describes the recent advances from the past five years concerning the development and applications of molecularly imprinted membranes (MIMs) in the field of sample treatment and separation processes. After a short introduction, where the importance of these materials is highlighted, a description of key aspects of membrane separation followed by the strategies of preparation of these materials is described. The review continues with several analytical applications of these MIMs for sample preparation as well as for separation purposes covering pharmaceutical, food, and environmental areas. Finally, a discussion focused on possible future directions of these materials in extraction and separation field is also given.

Highlights

  • Sample treatment is one of the most important stages in chemical analysis

  • The combination of membrane assisted solvent extraction and a molecularly imprinted polymers (MIPs) adsorbent (MASEMIP technique) into a single step format was described for extraction of polycyclic aromatic hydrocarbons (PAHs) in wastewater followed by their determination by GC-TOF/MS [49]

  • molecularly imprinted membranes (MIMs) are commonly used in selective molecular separation processes, including reverse osmosis, nanofiltration, pervaporation, and membrane adsorption

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Summary

Introduction

Sample treatment is one of the most important stages in chemical analysis. Its role is primarily focused on removing potentially interfering components present in the sample and as well as to preconcentrate the analytes to achieve the desired sensitivity. The resulting MIPs are stable, robust, and resistant to a wide range of pH, solvents and temperature, and exhibit advantages of stability, reusability, ease of use, and low cost of preparation [5,6] They exhibited large selectivity and an enhanced adsorption capability compared to their analogues synthesized in absence of template (NIPs). The review starts with an introduction of membrane media, including the different approaches, from the conventional in situ polymerization to the surface molecular imprinting strategies for the preparation of selective MIMs. the applications of the above-mentioned materials for the extraction or preconcentration of different target compounds in a wide range of matrices are described. A general conclusion as well as expected future trends of MIM media in sample preparation and separation purposes is included

Fundamental Aspects in Membrane Separation
Types of Strategies to Synthesize“conventional”
SEM of MIM
Schematic surface
Pharmaceutical and Clinical Applications
Food Applications
Environmental Applications
Use of MIMs in Separation Processes
Pharmaceutical and Food Applications
13. Separation process in nanofiltration
Findings
Conclusions

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