Recent Advances in Imaging of the Lung

Abstract

Lung has a complex cellular, physical and physiological architecture. To fully appreciate the normal and the altered cellular and physiological phenotype of the lung, it is critical to acquire cell‐specific and quantifiable information in intact lungs or isolated lung cells using relevant imaging methods. The integration of sound principles of morphometry with advanced light and ultrastructural imaging systems has provided quantification of cellular and molecular alterations in the lung. Recent use of intravital imaging has provided novel data on the interactions of leukocytes with lung microvascular endothelium and the responses of microvascular endothelium. Synchrotron radiation is also emerging as a tool to image changes in the living lung. This talk will provide an overview of the established and newly emerging imaging methods and their applications to the lung.