Abstract

AbstractFluoroalkylation serves as a pivotal strategy for chemists to precisely alter the properties of small molecules. Among the established fluoroalkylation protocols, sulfone and sulfinate reagents stand out as versatile tools for these reactions, particularly in mono-, di-, and trifluoromethylations. Their versatility lies in offering multiple pathways, encompassing electrophilic, nucleophilic, as well as radical mechanisms, thus providing diverse routes for controlled molecular modifications through a variety of very exciting mechanistic paths.1 Introduction2 Monofluoromethylation Strategies2.1 Fluorobis(phenylsulfonyl)methane (FBSM)2.2 2-Fluoro-1,3-benzodithiole-1,1,3,3-tetraoxide (FBDT)2.3 Benzothiazole-SO2CH2F, NaSO2CH2F, and ClSO2CH2F2.4 PhSO2CH2F3 Difluoromethylation Strategies3.1 PhSO2CF2H3.2 Benzothiazole-SO2CF2H3.3 2-PyrSO2CF2H3.4 NaSO2CF2H4 Trifluoromethylation Strategies4.1 PhSO2CF3 4.2 2-PyrSO2CF3 4.3 Benzothiazole-SO2CF3 4.4 NaSO2CF3 4.4.1 Electrochemical Approaches4.4.2 Photochemical Approaches4.4.3 Other Noteworthy Approaches5 Conclusion

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.