Abstract
Fiber-optic DNA biosensors are a kind of ana-lytic setups, which convert the Waston-Crick base pairs matching duplex or Hoogsteen’s tri-plex (T/A-T, C/G-C) formation into a readable analytical signals when functionalized single- strands DNA (ssDNA) or double-strands DNA (dsDNA) of interest are immobilized on the sur-face of fiber-optic hybrids with target DNA or interacts with ligands. This review will provide the information about the fiber-optic DNA bio-sensors classified into two categories depend-ing on the end fiber and side fiber with or with-out the labels—label-free fiber-optic DNA bio-sensors and labeled fiber-optic DNA biosensor in recent years. Both are dissertated, and em-phasis is on the label-free fiber-optic DNA bio-sensors. Fiber-optic DNA biosensors had got great progresses because fiber-optic has more advantages over the other transducers and are easily processed by nanotechnology. So fiber- optic DNA biosensors have increasingly at-tracted more attention to research and develop the new fiber-optic DNA biosensors that inte-grated with the “nano-bio-info” technology for in vivo test, single molecular detection and on-line medical diagnosis. Finally, future pros-pects to the fiber-optic DNA biosensors are predicted.
Highlights
Fiber-optic DNA biosensors are a kind of analytic setups, which convert the Waston-Crick base pairs matching duplex or Hoogsteen’s triplex (T/A-T, C/G-C) formation into a readable analytical signals when functionalized singlestrands DNA or double-strands DNA of interest are immobilized on the surface of fiber-optic hybrids with target DNA or interacts with ligands
This review will provide the information about the fiber-optic DNA biosensors classified into two categories depending on the end fiber and side fiber with or without the labels—label-free fiber-optic DNA biosensors and labeled fiber-optic DNA biosensor in recent years
Fiber-optic DNA biosensors are a kind of analytic setups, which convert the Waston-Crick base pairs matching duplex or Hoogsteen’s triplex (T/A-T or C/G-C) formation into a readable analytical signals when functionalized single-strands DNA or double-strands DNA [1,2] of interest are immobilized on the surface of side or end of fiber-optic hybrids with target
Summary
Fiber-optic DNA biosensors are a kind of analytic setups, which convert the Waston-Crick base pairs matching duplex or Hoogsteen’s triplex (T/A-T or C/G-C) formation into a readable analytical signals when functionalized single-strands DNA (ssDNA) or double-strands DNA (dsDNA) [1,2] of interest are immobilized on the surface of side or end of fiber-optic hybrids with target. Nanoparticles [14,15], nanotubes [16,17], nanowires [17,18,19,20,21,22,23] and fiber-optics as the matrices of DNA biosensors to detect DNA specific sequence and DNA hybridization have been reported. 2) Limited stability of biological component immobilized onto a fiber surface and limited availability of optimized commercial accessories for use with fiber-optic. 5) Existing techniques are difficult to directly characterize the functionalized surface of fiber because of small size
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