Recent advances in electrochemical transduction of chiral information

Abstract

Chirality governs many chemical and biological processes, since most active substances are chiral. Enantiomers are mirror images of the same molecule that can exhibit significant differences in terms of biochemical activity, toxicity, and transport mechanisms in the human body. Thus, developing effective methods to achieve chiral recognition is of great significance and has been a hot topic in chemo/biological studies. In recent years, electrochemical methods have received considerable attention in this field since they can offer several advantages over chromatographic or spectroscopic methods. In this review, a comprehensive and critical description of the trends in electrochemical chiral recognition over the last five years is presented. In addition, some unconventional electrochemical methods for the transduction of chirality at different length scales are described and discussed.