Abstract
Elastic liposomse (ELs) are the flexible liposomes formulated using phospholipids as well as edge activators. Edge activators provide elasticity to the Els. Els provide advantages over other formulations and have the ability to be delivered by different routes such as topical, transdermal, nasal, ocular, etc. Potential of encapsulating not only lipophillic but also hydrophillic drugs in a single vesicle, ability to pass through channels 1/10th of their diameter, increase in drug permeation, enhanced solubility of drug, patient compliance, prevention of degradation of drug makes them efficient carriers of drugs and leads to increased interest of researchers in them. This review provides understanding of composition of Els, advantages, method of preparation and the adaptable role played by ELs in the administration of numerous drugs for different diseases.
Highlights
Topical dosage form is a confined formulation, through which the drug can be administered anywhere in the body
This review provides understanding of composition of Els, advantages, method of preparation and the adaptable role played by Elastic liposomse (ELs) in the administration of numerous drugs for different diseases
Among the different carriers investigated for the topical delivery of drugs, ELs have been extensively investigated over the past few years due to their inherent advantages as compared to other vesicular carriers
Summary
Topical dosage form is a confined formulation, through which the drug can be administered anywhere in the body. ELs, commonly known as transferosomes, are biologically compatible double layered vesicular systems [2]. They comprise of phospholipids, surfactants which acts as edge activator (EA), and an interior hydrous cavity surrounded by double layer of lipid. ELs have been prepared for nasal, topical, transdermal delivery and for delivery of biologicals (vaccines and toxoids) dosage forms. Owing to their improved physicochemical and pharmacokinetic characteristics, ELs can overcome the problems associated with traditional drug delivery vehicles [2]
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