Abstract
Osteosarcoma, the predominant bone malignancy, poses significant challenges due to its high metastatic potential and recurrence rates. Accounting for a substantial percentage of malignant bone tumors, osteosarcoma particularly affects children and adolescents. Despite standard treatment combining surgery and multi-drug chemotherapy, systemic drug administration presents limitations, leading to compromised patient quality of life and severe side effects. New strategies are needed to address these challenges and enhance efficacy while minimizing toxicity. Here, we explore drug delivery platforms in the context of osteosarcoma treatment. We delve into both systemic and local delivery approaches, highlighting recent advances in controlled drug release triggered by various stimuli, modifications for targeted delivery, and co-delivery of chemotherapeutics using nano-platforms. Additionally, we discuss innovations in local delivery methods, including implantable nanoparticles, injectable hydrogels, and scaffolds. Despite these advancements, challenges and limitations persist, emphasizing the need for continued research. We conclude by offering perspectives on the potential of multifunctional scaffolds in revolutionizing osteosarcoma drug delivery, thereby paving the way for improved patient survival and enhanced quality of life.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
