Recent advances in cross-coupling reactions of trialkoxy titanium reagents (RTi(OR’)3) with electrophilic reagents

Abstract

Alkyl (aryl) titanium reagents are widely applied in organic synthesis because of their high nucleophilicity, low toxicity, relative stability and easy preparation. The cross-coupling reactions between organotitanium reagents and organic electrophilic reagents using transition-metal catalysts or photocatalysis provide a simple method for the synthesis of a variety of organic compounds. Compared with lithium and magnesium reagents, organotitanium reagents have better functional group tolerance, such as nitro, ester, hydroxyl, amino, cyano and lactone moieties, which are well compatible. Therefore, many organotitanium reagents have been widely applied in cross-coupling reactions in recent years. This review briefly summarizes the advances of alkyl (aryl) titanium reagents in cross-coupling reactions, involving various reaction systems.