Abstract
Copper-catalyzed cross-coupling reactions offer a powerful tool for the formation of carbonheteroatom bonds. Copper catalysis has an indisputable advantage over the other catalytic systems due to its low cost and the use of readily accessible and stable ligands. Among the various copper-catalyzed coupling reactions, C-S bond forming reactions have gained much attention due to its applications in the synthesis of molecules having biological and pharmaceutical impact. This review illustrates the current strategies and applications of Cucatalyzed C-S cross coupling reactions.
Highlights
The transition metal catalyzed cross-coupling reactions offer a powerful strategy for the construction of aryl-sulfur bonds
This review highlights the recent developments in copper-catalyzed carbon-sulfur bond forming reactions
The C-S bond forming reactions serve as powerful tools in synthetic organic chemistry for the synthesis of various molecules that are of biological, pharmaceutical and material interest
Summary
Thioethers are important class of compounds that are in great demand as intermediates in the synthesis of numerous compounds having biological and therapeutic applications and molecular precursors of material interest.[1,2,3,4] The transition metal catalyzed cross-coupling reactions offer a powerful strategy for the construction of aryl-sulfur bonds. This approach involves the coupling of organic halides with thiols. In recent years there is an upsurge of reports on C-S bond formation using various ligands such as phosphazene P2-Et base, neocuproine etc., primarily due to the high stability and low cost of copper
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