Abstract
Combined central and peripheral demyelination (CCPD) refers to the demyelination concurrently or sequentially occuring in the central and peripheral nervous systems. CCPD is a new disease entity, which is different from the independent central or peripheral nervous system demyelination. The pathogenesis of CCPD is unclear. The immune abnormalities may be involved. CCPD has low incidence, various manifestations, no specific biomarkers, and no uniform diagnostic criteria. This review summarizes the etiology, pathogenesis, clinical features, specific biomarkers, imaging characteristics, treatments and prognoses of CCPD to improve our understanding of CCPD. Key words: Combined central and peripheral demyelination; Anti-neurofascin 155 antibody; Immune abnormality
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