Abstract

Combined central and peripheral demyelination (CCPD) refers to the demyelination concurrently or sequentially occuring in the central and peripheral nervous systems. CCPD is a new disease entity, which is different from the independent central or peripheral nervous system demyelination. The pathogenesis of CCPD is unclear. The immune abnormalities may be involved. CCPD has low incidence, various manifestations, no specific biomarkers, and no uniform diagnostic criteria. This review summarizes the etiology, pathogenesis, clinical features, specific biomarkers, imaging characteristics, treatments and prognoses of CCPD to improve our understanding of CCPD. Key words: Combined central and peripheral demyelination; Anti-neurofascin 155 antibody; Immune abnormality

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.