Abstract
Endocytic pathways are broadly classified into clathrin dependent and independent on the basis of the requirement for the coat protein, clathrin. The molecular pathways and mechanisms underlying the formation of clathrin-independent pathways are still being explored, and this review summarizes recent advances and emerging functional roles of these diverse pathways. In particular, this review will discuss the growing consensus on the role of BAR domain proteins and the actin machinery in different clathrin-independent pathways and its significance to the functions fulfilled by these endocytic pathways.
Highlights
Endocytosis involves vesicular carriers that bud from the plasma membrane carrying membrane components, including signaling ligands, receptors, nutrients, or growth factors that are delivered to intracellular sites where they are further processed, recycled, or degraded
Secretion and endocytosis are closely integrated with the cellular protein synthesis and degradation machinery such that the flux of material through these processes is a key element in maintaining homeostasis in a cell
The convenient classification based on the requirement for the coat protein, clathrin, divides these endocytic processes into clathrin-dependent and clathrin-independent pathways[1,2,3]
Summary
F1000 Faculty Reviews are written by members of the prestigious F1000 Faculty. They are commissioned and are peer reviewed before publication to ensure that the final, published version is comprehensive and accessible. The reviewers who approved the final version are listed with their names and affiliations. Any comments on the article can be found at the end of the article
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