Recent advances in catalytic decarboxylative acylation reactions via a radical process.

Abstract

The decarboxylative cross-coupling reactions of carboxylic acids have emerged as an efficient strategy for the C-C bond and C-X bond formations. In this field, the decarboxylative cross-coupling of α-keto acids has been developed as an attractive strategy to introduce a carbonyl group into versatile organic molecules. In particular, radical-mediated decarboxylative reactions have attracted much attention of chemists owing to their mild conditions, excellent functional group tolerance and high reactivity. In this review, we highlight the recent advances in the radical decarboxylative acylation reactions of α-keto acids.