Recent advances in C-heteroatom bond forming by asymmetric Michael addition

Abstract

In this review, we try to highlight the recently reported stereoselective Michael conjugate additions of heteroatom nucleophiles to electron-deficient alkenes. The topic is divided based on the nature of the nucleophile employed (nitrogen-, oxygen-, sulfur-, or phosphorus-centered) and then subdivided to distinguish between catalyst-controlled and substrate/reagent-controlled methods which is necessary to achieve asymmetric synthesis.