Abstract
The asymmetric conjugate addition of carbon and heteroatom nucleophiles to nitroalkenes is a very interesting tool for the construction of highly functionalized synthetic building blocks. Thanks to the rapid development of asymmetric organocatalysis, significant progress has been made during the last years in achieving efficiently this process, concerning chiral organocatalysts, substrates and reaction conditions. This review surveys the advances in asymmetric organocatalytic conjugate addition reactions to α,β-unsaturated nitroalkenes developed between 2013 and early 2017.
Highlights
Asymmetric organocatalysis is still a relatively young field for the chemical research community
The present section has been classified according to the carbon pro-nucleophiles employed in the asymmetric addition to nitroalkenes
L-Proline was the first organocatalyst employed in the asymmetric conjugate addition reaction of carbo2n.1y.lAcoldmehpyodeusnds to nitroalkenes [28,29]
Summary
Asymmetric organocatalysis is still a relatively young field for the chemical research community. The asymmetric organocatalyzed conjugate addition of carbon nucleophiles to α,β-unsaturated nitroalkenes has attracted considerable attention, as the final enantioenriched γ-nitrocarbonyl compounds can be transformed into compounds of interest [13,14,15,16,17]. The present review covers asymmetric organocatalytic conjugate addition reactions to α,β-unsaturated nitroalkenes published from 2013 till the first quarter of 2017, concerning substrates, organocatalysts and reactions conditions.
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