Abstract
Asymmetric transition-metal catalysis represents a fascinating challenge in the field of organic chemistry research. Since seminal advances in the late 60s, which were finally recognized by the Nobel Prize to Noyori, Sharpless and Knowles in 2001, the scientific community explored several approaches to emulate nature in producing chiral organic molecules. In a scenario that has been for a long time dominated by the use of late-transition metals (TM) catalysts, the use of 3d-TMs and particularly iron has found, recently, a widespread application. Indeed, the low toxicity and the earth-abundancy of iron, along with its chemical versatility, allowed for the development of unprecedented and more sustainable catalytic transformations. While several competent reviews tried to provide a complete picture of the astounding advances achieved in this area, within this review we aimed to survey the latest achievements and new concepts brought in the field of enantioselective iron-catalyzed transformations.
Highlights
Transition metal catalysis represents a powerful tool for the construction of highly functionalized molecules in organic synthesis
The development of more sustainable, cheaper and stereoselective synthetic methodologies are crucial for the future
As emerged by this review, asymmetric iron catalysis represents a clear and potentially ground-breaking alternative to the well-established 4d and 5d metals-catalyzed reactions. This has been made possible by controlling the catalytic activity of iron catalysts through a proper choice of ligands
Summary
Transition metal catalysis represents a powerful tool for the construction of highly functionalized molecules in organic synthesis. Major advances were need to emulate nature led to the development of a remarkable number of iron-catalyzed subsequently achieved with the introduction of chiral ligands such as oxazolines (i), NHCs (ii) or enantioselective methodologies, initially using chiral iron porphyrin complexes [21,22,23]. The use ofiron achiral ligands, asymmetrically coordinated around the metal opened access tocoordination catalytically sphere active chiral-at-metal iron asymmetric induction could be alsocenter, induced by a second (v), usually constituted complexes (iv). Asymmetric induction could be induced by a second coordination by bio macromolecules, namely enzymes or DNAs. The aim(v), of usually this review is to provide overview of thenamely last advances inor enantioselective iron-catalyzed. Last three years (2018, 2019 and 2020) will be covered with few references from the previous two years
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