Abstract
Antimicrobial resistance constitutes one of the major challenges facing humanity in the Twenty-First century. The spread of resistant pathogens has been such that the possibility of returning to a pre-antibiotic era is real. In this scenario, innovative therapeutic strategies must be employed to restrict resistance. Among the innovative proposed strategies, anti-virulence therapy has been envisioned as a promising alternative for effective control of the emergence and spread of resistant pathogens. This review presents some of the anti-virulence strategies that are currently being developed, it will cover strategies focused on quench pathogen quorum sensing (QS) systems, disassemble of bacterial functional membrane microdomains (FMMs), disruption of biofilm formation and bacterial toxin neutralization.
Highlights
Antimicrobial resistance has turned a serious concern to the human health, because in addition to the death caused by drug-resistant pathogens (∼700,000 death annually and it is estimated ∼10 million for the year 2050), important medical procedures such as organ transplantation, cancer chemotherapy and surgery are compromised (O’Neill, 2016)
Among the new therapeutic strategies, anti-virulence therapy has emerged as a promising alternative since instead of killing the pathogens; it tries to deprive them from their virulence factors
This study show the potential of anti-functional membrane microdomains (FMMs) drugs to revert an antibiotic-resistant phenotype into an antibioticsensitive phenotype
Summary
Antimicrobial resistance has turned a serious concern to the human health, because in addition to the death caused by drug-resistant pathogens (∼700,000 death annually and it is estimated ∼10 million for the year 2050), important medical procedures such as organ transplantation, cancer chemotherapy and surgery are compromised (O’Neill, 2016). Some of these halogenated analogs showed effectivity in vivo in reducing the virulence and limiting P. aeruginosa systemic dissemination in infected mice (Lesic et al, 2007).
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