Abstract
The interferon response protects cells from invading viral pathogens by transcriptionally inducing the expression of interferon-stimulated genes (ISGs), some of which encode effectors with varied antiviral functions. As screening technologies improve and mouse model development quickens, more ISGs are continually being identified, characterized mechanistically, and evaluated for protective roles in vivo. This review highlights selected recent findings of ISG effectors that contribute to our understanding of the interferon antiviral response.
Highlights
A major component of cell-intrinsic antiviral defense in higher eukaryotes is the interferon (IFN) response
IFNs activate JAK–STAT signaling, which leads to the transcriptional induction of hundreds of IFN-stimulated genes (ISGs)
In functional viral infection assays in mammalian cells, the authors further delineated the non-overlapping antiviral specificity of IFIT1 and IFIT1B for different viruses. They confirmed that IFIT1B suppressed the translation of viruses with cap(0) but not cap(1) structures
Summary
F1000 Faculty Reviews are written by members of the prestigious F1000 Faculty. They are commissioned and are peer reviewed before publication to ensure that the final, published version is comprehensive and accessible. The reviewers who approved the final version are listed with their names and affiliations. Any comments on the article can be found at the end of the article
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