Abstract
Metal ions play important roles in biological system. Approaches capable of selective and sensitive detection of metal ions in living biosystems provide in situ information and have attracted remarkable research attentions. Among these, fluorescence probes with aggregation-induced emission (AIE) behavior offer unique properties. A variety of AIE fluorogens (AIEgens) have been developed in the past decades for tracing metal ions. This review highlights recent advances (since 2015) in AIE-based sensors for detecting metal ions in biological systems. Major concerns will be devoted to the design principles, sensing performance, and bioimaging applications.
Highlights
Metal ions play crucial roles in various biological processes and are required by all life forms.The diverse functions of metal ions include osmotic maintenance, signal transduction, catalysis, and proliferation [1]
aggregation-induced emission (AIE) cores play the role of signal ion detection, this review focuses on recent development of AIE-based sensors for detecting and output, while modifications on AIE structures enable the selective recognition
Given the importance of metal ions and the continuously growing body of AIE fluorogens (AIEgens) for metal ion detection, this review focuses on recent development of AIE-based sensors for detecting and imaging
Summary
Metal ions play crucial roles in various biological processes and are required by all life forms. Tang’s group in functional2001 molecules and materials, such as nucleic acids, peptides, graphene, and metal-organic possess unique advantages of activatable emission, good photostability, and compatibility with high concentration high sensitivity [20]. These fluorophores are non-emissive or weakly frameworks (MOFs) [26,27,28,29]. AIE cores play the role of signal ion detection, this review focuses on recent development of AIE-based sensors for detecting and output, while modifications on AIE structures enable the selective recognition. The disappearance of the blue emission after the treatment K+ suppressing reagents confirmed the feasibility and reversibility of this probe for detection and imaging of K+
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