Abstract
Surface-enhanced Raman scattering (SERS) has been widely utilized in early detection of disease biomarkers, cell imaging, and trace contamination detection, owing to its ultra-high sensitivity. However, it is also subject to certain application restrictions in virtue of its expensive detection equipment and long-term stability of SERS-active substrate. Recently, great progress has been made in SERS technology, represented by agglomeration method. Dual readout signal detection methods are combined with SERS, including electrochemical detection, fluorescence detection, etc., establishing a new fantastic viewpoint for application of SERS. In this review, we have made a comprehensive report on development of agglomeration detection and dual-function detection methods based on SERS. The synthesis methods for plasmonic materials and mainstream SERS enhancement mechanism are also summarized. Finally, the key facing challenges are discussed and prospects are addressed.
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