Abstract

The abstract is not provided being a short comunication / featured article.

Highlights

  • Antimicrobial resistance (AMR) is one of the leading causes of death globally

  • Recent estimates reveal that 1.2 million deaths were due to resistant bacterial infections in 2019 and 4.95 million deaths were associated with resistant bacterial infections [1]

  • This includes nourishing the pipeline, investing in the development of new therapies knowing that research and development (R&D) of safe and effective products takes time, and adopting policy at the government level such as advanced remuneration frameworks to create a viable environment for new products [2]

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Summary

Recent advances and challenges in antibacterial drug development

Impact Initiatives and Research Coordination Unit, Global Coordination Department, AMR Division, WHO, Geneva, Switzerland. The pandemic has marginalized many public health priorities and programs in countries, resulting in services and programs interruption such as disease surveillance This all together threatens the gains made in recent years against AMR. Today WHO pipeline review is the only global analysis that regularly covers antibacterial agents in development by large pharmaceutical companies as well as by medium and small size enterprises [4]. Findings from this analysis are featured in an annual WHO publication and the data are made public through WHO R&D Observatory [5] as well as the Global AMR R&D Hub. Findings from this analysis are featured in an annual WHO publication and the data are made public through WHO R&D Observatory [5] as well as the Global AMR R&D Hub Overall, this information allows for secondary analyses such as the estimation of the source and number of investments across the different development phases as shown in the Global AMR R&D Hub dashboard [6,7]

The long road to approval
Surviving the market and proving the value
Innovation in traditional antibacterial agents
Findings
Final thoughts
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