Abstract
Colorectal cancer is the second most deadly type of cancer (CRC). In the upcoming decades, death and incidence rates would surely increase globally. Despite being disproportionately high in high-income countries, CRC-related mortality is also on the rise in low- and middle-income countries. Early diagnosis of CRC allows for both surgical and medicinal treatment options. Due to the high likelihood of recurrence and the rising rate of treatment failure brought on by cancer medicine resistance, it is regrettable that there is a significant treatment failure rate. Due to early discovery and treatment of CRC, there is a chance of survival in wealthy nations. Contrarily, these resources are noticeably scarce in less developed countries. It is crucial to inform the public about CRC's current situation, its cause, progression, risk factors, and therapy. As a result, we have included in this review all of the most recent data on the global epidemiology, drug resistance, challenges, risk factors, and preventative and therapeutic approaches for CRC. Guidelines for CRC prevention and therapy are briefly reviewed, as well as pathways of CRC developments.
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