Abstract
Metabolism has been a focus of cancer research in the last few years, and researchers have found that many pathways associated with tumor growth were related to metabolic pathways. The ketogenic diet (high fat, low carbohydrate and protein) caused metabolic changes, such as a reduction in blood glucose and an increase in blood ketones. Findings indicated that ketogenic diet could reduce the energy for cancer cells and inhibit tumor growth; furthermore, it did not significantly affect the energy metabolism and physiology of body. To date, ketogenic diet is considered as an anti-angiogenic, anti-metastatic and pro-apoptotic metabolic therapy, and the metabolic therapy has the potential to improve the outcome of patients with glioblastoma multiforme and other malignant brain cancers. In this review, we discuss the research progresses about anti-brain tumor effect of ketogenic diet and its related mechanism. Key words: Ketogenic diet; Brain glioma; Energy metabolism; Anti-tumor effect
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