Abstract

The pathogenesis of Alzheimer's disease (AD) has not been fully elucidated. Mitochondria play critical roles in neuronal function; and damage of hippocampal neurons by dysfunction of mitochondrial dynamics is the major pathological mechanism of AD. Improvement of mitochondrial dynamics imbalance in time should alleviate or reverse damage of hippocampal neurons. After a brief overview of basic mechanisms involved in regulation of mitochondrial fission, fusion, and transportion, and how mitochondrial dynamics affects AD, this review article focuses on discussing the role of key sites such as Drp1, Mfn1/2, Opa1 and Miro/Milton in regulating mitochondria dynamics and their effects on AD. Key words: Mitochondrial dynamic; Alzheimer's disease; Neuron damage

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