Abstract
The subject of this review article refers to the recent achievements in the investigation of pharmacological activity and supramolecular characteristics of betulinic acid and its diverse derivatives, with special focus on their cytotoxic effect, antitumor activity, and antiviral effect, and mostly covers a period 2015–2018. Literature sources published earlier are referred to in required coherences or from historical points of view. Relationships between pharmacological activity and supramolecular characteristics are included if such investigation has been done in the original literature sources. A wide practical applicability of betulinic acid and its derivatives demonstrated in the literature sources is also included in this review article. Several literature sources also focused on in silico calculation of physicochemical and ADME parameters of the developed compounds, and on a comparison between the experimental and calculated data.
Highlights
Plants represent an important challenge in searching for new plant products, of which a majority of new structures displays drug-like properties in treating serious diseases
Attention has been focused on betulinic acid and its derivatives
Betulinic acid is a very potent plant triterpenoid compound with a broad spectrum of its own activity and a broad spectrum of pharmacologically important derivatives
Summary
Plants represent an important challenge in searching for new plant products, of which a majority of new structures displays drug-like properties in treating serious diseases. This plant product product had had been been subsequently plant sources, and,and, described by different trivial names subsequently isolated isolatedfrom fromdifferent different plant sources, described by different trivial (e.g., platanolic acid, cornolic acid, melaleucin, etc.), identified as betulinic acid names (e.g., platanolic acid, cornolic acid, melaleucin, etc.), identified as betulinic (1, 1) [5] It isItaisnaturally occurring pentacyclic acidFigure a naturally occurring pentacycliclupane-type lupane-typetriterpene, triterpene,found found throughout throughout the plant kingdom 1 was found inas different plants, and in forms of glycosylated derivatives that enhance its bioavailability [2,3] Isolation of from both as a free aglycon and in forms of glycosylated derivatives that enhance its bioavailability plant sources not easy, it is accompanied a number other terpene-based plant products.
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