Abstract
SummaryResistance to Ehrlich ascites tumour growth in the peritoneal cavity of mice has been induced by prior immunisation with live Salmonella enteritidis 11RX. A greater and longer lasting anti‐tumour effect was elicited after immunisation by the intraperitoneal (i.p.) route than by the intravenous (i.v.) route. Resistance to tumour could be recalled after either i.p. or i.v. immunisation by i.p. injection of various 11RX antigen preparations, including a preparation which was not protective in normal mice. Resistance was determined by following survival of mice after challenge with tumour cells and by monitoring the death of 131I‐iododeoxyuridine‐labelled tumour cells in vivo. Recall of tumour resistance was attributed to the rapid induction of an in vivo tumour killing mechanism.
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