Abstract
We examined the effect of rebamipide on the vasospasm induced by periarterial blood. In the in vitro study, the significant production of superoxide anion that was identified 3 hours after application of 10% whole blood to the rat aortic segments was inhibited by rebamipide (100 and 300 μ M) and these results were correlated with the in vitro intercellular adhesion molecule-1 (ICAM-1) expression on the femoral artery. In thein vivo study, there was an increased mobilization of granulocytes in parallel with a large expression of ICAM-1 in the vessels 24 hours after periarterial blood was applied to the femoral artery which then declined. Subsequently, infiltration of macrophages progressively increased at all layers 7–12 days after application. Pretreatment with rebamipide (100 and 300 mg kg−1day−1, p.o.) significantly inhibited the morphological changes as well as the expression of ICAM-1 with inhibition of granulocyte/macrophage mobilization. In association with these findings, increased wall thickness and decreased lumen area were significantly inhibited by pretreatment with rebamipide. These results provide valuable information for the therapeutic use of rebamipide to relieve vascular remodeling induced by periarterial blood.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
