Rebalancing binocular vision in amblyopia

Abstract

Humans with amblyopia have an asymmetry in binocular vision: neural signals from the amblyopic eye are suppressed in the cortex by the fellow eye. The purpose of this study was to develop new models and methods for rebalancing this asymmetric binocular vision by manipulating the contrast and luminance in the two eyes. We measured the perceived phase of a cyclopean sinewave by asking normal and amblyopic observers to indicate the apparent location (phase) of the dark trough in the horizontal cyclopean sine wave relative to a black horizontal reference line, and used the same stimuli to measure perceived contrast by matching the binocular combined contrast to a standard contrast presented to one eye. We varied both the relative contrast and luminance of the two eyes' inputs, in order to rebalance the asymmetric binocular vision. Amblyopic binocular vision becomes more and more asymmetric the higher the stimulus contrast or spatial frequency. Reanalysing our previous data, we found that, at a given spatial frequency, the binocular asymmetry could be described by a log-linear formula with two parameters, one for the maximum asymmetry and one for the rate at which the binocular system becomes asymmetric as the contrast increases. Our new data demonstrates that reducing the dominant eye's mean luminance reduces its suppression of the non-dominant eye, and therefore rebalances the asymmetric binocular vision. While the binocular asymmetry in amblyopic vision can be rebalanced by manipulating the relative contrast or luminance of the two eyes at a given spatial frequency and contrast, it is very difficult or even impossible to rebalance the asymmetry for all visual conditions. Nonetheless, wearing a neutral density filter before the dominant eye (or increasing the mean luminance in the non-dominant eye) may be more beneficial than the traditional method of patching the dominant eye for treating amblyopia.