Abstract
Experiments were done on 12 urethane-chloralose anaesthetized, vagotomized, paralysed and ventilated cats. The effects of electrical microstimulation at the augmenting expiratory neurons (Aug-e) of Bötzinger complex (Bot.c) were investigated. It was found that long train stimulation (100 Hz, 3–50 μA, 4–6 s) caused intensity-dependent inhibition of phrenic inspiratory discharge. The threshold for complete inhibition was 10 ± 2 μA (mean ± S.E.). The expiratory duration showed shortening at low intensity (<7 μA) and prolongation at higher intensity. Short train stimulation (10 μA, 50 ms) delivered in inspiratory phase produced a two-part transient inhibition of phrenic discharge. The latencies of the first- and second-part inhibition were 4.7 ± 0.16 ms and 95 ± 3 ms, respectively. Complete termination of inspiration could be produced by a short train delivered at late inspiration. The results suggest the importance of the Aug-e neurons of Bot.c in determining inspiratory amplitude and respiratory phase duration.
Published Version
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