Abstract
This research focuses on developing a sensitive nanoelectronic device (NED) with impedimetric detection of human cardiac troponin I (cTnI) for the real-time diagnosis of acute myocardial infarction. The sensing area of NED was composed of indium tin oxide (ITO)-coated vertically aligned silicon nanowires (VASiNWs). ITO-coated-VASiNWs were examined by X-ray diffraction and scanning electron microscope for the identification of crystalline structure and morphological observation, respectively. After cTnI antibody (cTnIAb) modification, various concentrations of cTnI in the human blood sera were then impedimetrically detected by cTnIAb-modified-ITO-coated-VASiNWs via microfluidic systems. Our device exhibited a linear range from 1.76011 to 17601.1 ng/mL with good sensitivity for the detection of cTnI.
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