Abstract
Background: to research retrospectively the efficacy of Erenumab’s treatment, thus allowing to describe a summary more in line with the reality observed every day in clinical practice, relative to a sample of patients widely heterogeneous. The study aims to confirm the efficacy of Erenumab, in terms of reduction of migraine days per month, from baseline to month 12 of treatment. Additional objectives included a reduction in the number of days of symptomatic drug use and change from baseline in the Migraine Disability Assessment Score Questionnaire (MIDAS); Methods: the analysis included all patients treated for 12 months with Erenumab during the year 2019–2020. The population analyzed consists of twenty-six patients from the Neurology outpatient clinic in Fossombrone. Several quantitative and qualitative variables were recorded by reading the medical records of the patients. The MIDAS was administered to patients to assess the disability related to migraine; Results: at the end of treatment, a statistically significant reduction in the mean number of monthly migraine days, acute medication use per month, and MIDAS questionnaire score was observed; Conclusions: as a preventive treatment of episodic and chronic migraine, our analysis data confirm the efficacy of Erenumab for the prevention of the migraine. The success is achieved in 96% of cases.
Highlights
Migraine is the third most prevalent and the second most disabling disease worldwide.Migraine is characterized by recurrent headache episodes of moderate to severe intensity that last 4–72 h associated with neuro-vegetative symptoms [1]
Migraine pain is underlined by a dysfunctional trigeminal system, which consists of the Central Nervous System (CNS) and peripheral structures
The confirmation of the validity of CGRP as a therapeutic target represents an extraordinary opportunity for the field of anti-migraine medicine in accordance with what has already been demonstrated by clinical trials
Summary
Migraine is the third most prevalent and the second most disabling disease worldwide.Migraine is characterized by recurrent headache episodes of moderate to severe intensity that last 4–72 h associated with neuro-vegetative symptoms [1]. Despite the availability of these different therapeutic options, which were not developed for migraine prophylaxis, patients have numerous unmet therapeutic needs This is because these therapies are associated with significant side effects that, together with the frequency of administration, poor results and not less than direct and indirect health care costs affect compliance and adherence. All of this constitutes a significant limitation for the management of patients with migraine pain and represents a risk for medication overuse and possible abuse of symptomatic drugs with chronicity of the disease [9,10]
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