Abstract
A μPCR system and its Electrochemical (EC) detection circuits are presented. The system consists of a μPCR chip packaged on a printed circuit board (PCB), peripheral signal read-out circuits and control circuits. The μPCR chip is realized with MEMS-technology contains an array of 3×4 reaction chamber. A microcontroller unit (MCU) is used in the control system to monitor the reaction procedure (PCR cycling) and handle the signal measurement. A Logarithmic Current Mode Amplifier (LGCMA) is proposed and realized as the EC signal amplification and I-V conversion. The test results shows that the obtained chip presents good Logarithmic DC characteristics within a current change from 1nA to 1μA and the corresponding output is from -4.43V to -3.52V. Thermal cycling experiment was carried to verified the control system, The results show that the variation of temperature is 0.1°C at the stable state.
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