Abstract
Acute lymphoblastic leukemia (ALL) is an aggressive bone marrow cancer with disparate outcomes. Data on patient outcomes in real world settings outside of clinical trials is limited. The current study reports on outcomes for 137 ALL patients who received an adult induction and consolidation regimen derived from the CALGB 10102 trial modified without alemtuzumab. Of the 137 patients, 32 were < 40years old, 52 were between 40 and 59, and 53 were ≥ 60years old. Overall, 109 (79.6%) patients achieved a complete remission (< 40: 96.1%, 40-59: 86.5%, and 62.3% ≥ 60 (p = 0.0002)). Progression free survival for the entire cohort was 13.5months and by age was 19.8months for less than 40, 23.4months for 40 to 59 and 6.7months for ≥ 60; p = 0.0002. Median survival was 22.1months for the entire cohort (32.9months for ages < 40, 26.6months ages 40-59, 7.8months ≥ 60, p < 0.001).
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