Abstract
The nuclear receptor superfamily have crucial roles in many physiological and pathological processes, including embryogenesis and cancer. Members of this superfamily can be grouped according to their subcellular localization. Some, including retinoic acid receptor (RAR), exhibit constitutive nuclear localization, whereas many members of the steroid receptor family, including the glucocorticoid receptor (GR), are cytoplasmic and only shift to the nucleus upon ligand binding. This property makes the latter type of receptors much more useful for studying ligand–receptor interactions. By following the movement of such a receptor as a chimera with green fluorescent protein (GFP), it is possible to visualize the receptor response to ligand binding in real time. The study of more travel-shy receptors, such as RAR, would benefit from a similar tool.
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