Abstract
A simple and fast time-domain method for localizing inclusions, fluorescent optical probes or absorbers, is presented. The method offers new possibilities for situations where complete tomographic measurements are not permitted by the examined object, for example in endoscopic examination of the human prostate or the oesophagus. Feasibility has been envisioned with a phantom study conducted on a point-like fluorochrome embedded in a diffusing medium mimicking the optical properties of biological tissues.
Highlights
The interest in optical techniques for biological tissues screening has grown in the last decade because they represent a non invasive and non ionizing method for diagnosis or imaging [1]
The method offers new possibilities for situations where complete tomographic measurements are not permitted by the examined object, for example in endoscopic examination of the human prostate or the oesophagus
The feasibility has been envisioned with a phantom study conducted on a point-like fluorochrome embedded in a diffusing medium mimicking the optical properties of biological tissues
Summary
The interest in optical techniques for biological tissues screening has grown in the last decade because they represent a non invasive and non ionizing method for diagnosis or imaging [1]. Time resolved techniques are those who carry the richest information on the optical properties of the crossed tissue, and seem to be those that are more suitable for deep tissue screening (several centimeters for brain or breast examination) [2,3]. They are those for which the reconstruction techniques are the most sophisticated and become sometimes intractable for real time resolution of the inverse problem. The resolution of the inverse problem leads to the determination of the unknowns, that can be the three-dimensional (3D) distribution of the optical parameters (absorption and diffusion coefficients) in DOT or/and the properties of an optical probe (concentration, lifetime), such as in Fluorescence DOT (FDOT). The method allows a localization of the fluorescent inclusions without reconstruction, with a limited number of sources and detectors points
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