Abstract
This talk will focus on the use of cutting-edge high resolution structural visualization combined with dynamic live cell and single-molecule fluorescence imaging techniques to understand clathrin mediated endocytic processes involved in communication of cells with its environment, in pathogen invasion and viral infection, in cell growth control and cancer, and in the biogenesis of organelles. The goal is to generate molecular-resolution movies describing the function of machineries responsible for the control of these types of carefully choreographed interactions in cells. We will explore the regulation of the clathrin machinery engaged in classical endocytosis by presenting an integrated view based on recent data from snapshots (cryoEM tomography and 3-D single-particle reconstruction, x-ray crystallography) and from dynamic imaging (live cell and single molecule fluorescence microscopy) and show how they are used to inform cell, biochemical and mechanistic studies.
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