Abstract
Direct nucleation control (DNC) is a process analytical technique (PAT) based model free feedback control strategy for batch and continuous crystallization processes, which has been successfully applied in numerous cases. The basic principle of DNC is the use of controlled dissolution cycles to control a measurement directly related to the particle number in the system. During DNC, in the case of cooling crystallization fines are dissolved by repeated heating–cooling loops. In this context, the controlled variable is the (relative) particle number, which is manipulated using a feedback control approach through the temperature. The particle number is traditionally measured with focused beam reflectance measurement (FBRM); however, other PAT tools can also be employed in a similar feedback control setup. Often, crystallization processes are also monitored by real-time imaging systems. In the current work a novel DNC setup is proposed in which microscopy images are captured and processed by means of image an...
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